Artikel van Sciencemag uit 2015, God weet wat er nu mogelijk is.
DNA ‘vaccine’ sterilizes mice, could lead to one-shot birth control
Animal birth control could soon be just a shot away: A new injection makes male and female mice infertile by tricking their muscles into producing hormone-blocking antibodies. If the approach works in dogs and cats, researchers say, it could be used to neuter and spay pets and to control reproduction in feral animal populations.
A similar approach could one day spur the development of long-term birth control options for humans.
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To get there, researchers have already created vaccines that trigger an immune response in animals. This response produces antibodies that block gonadotropin-releasing hormone (GnRH), required by all mammals to turn on the pathways that spur egg or sperm development. The vaccines in this class—including deer contraceptive GonaCon—have been shown to effectively work as both male and female birth control in animals. But, like many human immunizations, the vaccines rely on an immune response that eventually dwindles away,
forcing the use of booster shots every few years.
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Hay’s team also showed that the same approach could be used to make female mice generate antibodies to the zona pellucida, a layer of proteins that surrounds egg cells. In these cases, animals continue to produce eggs but sperm can’t fertilize them. The advantage to blocking these proteins, Hay says, is that the treatment doesn’t affect hormone levels, which are critical in regulating all types of behavior.
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Hay’s team is now testing their new approach to block other hormones and proteins in mice. “There are a lot of other molecules we can try to target now that we know this works.”