Lievergezond
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Curcumin inhibits bTREK-1 K+ channels and stimulates cortisol secretion from adrenocortical cells. -
Curcumin inhibits bTREK-1 K+ channels and stimulates cortisol secretion from adrenocortical cells.
Abstract Source:
Biochem Biophys Res Commun. 2008 Jun 13;370(4):623-8. Epub 2008 Apr 10. PMID: 18406348
Abstract Author(s):
Judith A Enyeart, Haiyan Liu, John J Enyeart
These results demonstrate that curcumin potently inhibits bTREK-1 K(+) channels and stimulates cortisol secretion from bovine AZF cells. The inhibition of bTREK-1 by curcumin may be linked to cortisol secretion through membrane depolarization. Since TREK-1 is widely expressed in a variety of cells, it is likely that some of the biological actions of curcumin, including its therapeutic effects, may be mediated through inhibition of these K(+) channels. http://www.greenmedinfo.com/article...-k-channels-and-stimulates-cortisol-secretion
http://www.ncbi.nlm.nih.gov/pubmed/18406348
Curcumin inhibits bTREK-1 K+ channels and stimulates cortisol secretion from adrenocortical cells.
Abstract Source:
Biochem Biophys Res Commun. 2008 Jun 13;370(4):623-8. Epub 2008 Apr 10. PMID: 18406348
Abstract Author(s):
Judith A Enyeart, Haiyan Liu, John J Enyeart
These results demonstrate that curcumin potently inhibits bTREK-1 K(+) channels and stimulates cortisol secretion from bovine AZF cells. The inhibition of bTREK-1 by curcumin may be linked to cortisol secretion through membrane depolarization. Since TREK-1 is widely expressed in a variety of cells, it is likely that some of the biological actions of curcumin, including its therapeutic effects, may be mediated through inhibition of these K(+) channels. http://www.greenmedinfo.com/article...-k-channels-and-stimulates-cortisol-secretion
http://www.ncbi.nlm.nih.gov/pubmed/18406348