Wanna know what all these drugs have in common?
They’re all anti-parasitic
And
They’re all anti-cancer
Weird coincidence, eh?
(What it cures already exist)
Moxidectin induces Cytostatic Autophagic Cell Death of Glioma Cells through inhibiting the AKT/mTOR Signalling Pathway
Moxidectin induces Cytostatic Autophagic Cell Death of Glioma Cells through inhibiting the AKT/mTOR Signalling Pathway
Moxidectin (MOX), a broad-spectrum antiparasitic drug, has been characterized as a potential anti-glioma agent. The main objective of this study was to explore autophagy induced by MOX in glioma U251 and C6 cells, and the deep underlying molecular mechanisms. In addition, the effects of...
pubmed.ncbi.nlm.nih.gov
The anthelmintic agent oxfendazole inhibits cell growth in non‑small cell lung cancer by suppressing c‑Src activation
The c‑Src protein family of tyrosine kinases are important in the tumorigenesis of many types of tumors, and may be a potential target for antitumor drug discovery. In the present study, immunoblotting was performed to analyze protein expression, CCK‑8 assay was carried out to assess cell...
www.spandidos-publications.com
Ivermectin Antiparasitic Anticancer Wonder Drug
Antiparasitic Drug Ivermectin Has Remarkable Anti-Cancer Activity.
jeffreydachmd.com
The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
Drug repositioning is a highly studied alternative strategy to discover and develop anticancer drugs. This drug development approach identifies new indications for existing compounds. Ivermectin belongs to the group of avermectins (AVM), a series of ...
www.ncbi.nlm.nih.gov
Unexpected antitumorigenic effect of fenbendazole
Diet containing the anthelminthic fenbendazole is used often to treat rodent pinworm infections because it is easy to use and has few reported adverse effects on research. However, during fenbendazole treatment at our institution, an established human lymphoma xenograft model in...
pubmed.ncbi.nlm.nih.gov
A Drug For Animals Now Taken By Humans For Cancer: Fenbendazole
Previously, we discussed on this website the anti-worm drug Mebendazole (Ref.), which based on a good amount of scientific and clinical evidence, shows relevant anti cancer potential. However, as we saw, it’s not only science. Instead, there are case reports published in peer review papers...
principia-scientific.com
The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs
The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival. Benzimidazole anthelmintics have broad-spectrum action to ...
www.ncbi.nlm.nih.gov
Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents
The use of albendazole and mebendazole, i.e., benzimidazole broad-spectrum anthelmintics, in treatment of parasitic infections, as well as cancers, is briefly reviewed. These drugs are known to block the microtubule systems of parasites and ...
www.ncbi.nlm.nih.gov
Mebendazole as a Candidate for Drug Repurposing in Oncology
Anticancer treatment efficacy is limited by the development of refractory tumor cells characterized by increased expression and activity of mechanisms promoting survival, proliferation, and metastatic spread. The present review summarizes the ...
www.ncbi.nlm.nih.gov
Niclosamide Exhibits Potent Anticancer Activity
Niclosamide may be repurposed as a potent anticancer agent, which can potentiate the anticancer activity of the other agents targeting different signaling pathways in the treatment of human RCC.
pubmed.ncbi.nlm.nih.gov
Molecular mechanisms of niclosamide antitumor activity
In this review the recent data regarding the antitumor activity of niclosamide and the molecular mechanisms of its antitumor activity are presented. Niclosamide has been used in the clinic for the treatment of intestinal parasite infections. In recent years in several screening investigations of...
pubmed.ncbi.nlm.nih.gov
Niclosamide: Beyond an antihelminthic drug
Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of people worldwide. However recent studies have indicated that niclosamide may have broad clinical applications for the treatment of diseases other than those ...
www.ncbi.nlm.nih.gov
Oxibendazole inhibits prostate cancer cell growth
Prostate cancer (PCa) is one of the most common malignancies among men and is the second leading cause of cancer‑associated mortality in the developed world. Androgen deprivation therapy (ADT) is the most common treatment for PCa. However, the majority of androgen‑sensitive PCa patients will...
www.spandidos-publications.com
Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer agents
Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the treatment of cancer. Overall, preclinical studies support CQ and HCQ use in anti-cancer therapy, especially in combination with...
pubmed.ncbi.nlm.nih.gov